Receptor tyrosine-protein kinase erbB-2 (ERBB2). Protein tyrosine kinase that is part of several cell surface receptor complexes. In the nucleus it is involved in transcriptional regulation. Enhances protein synthesis and cell growth.
NCT03740256 -
Bladder Cancer, Breast Cancer, Colorectal Cancer, Esophagus Cancer, Head
and Neck Squamous Cell Carcinoma, Lung Cancer, Pancreatic Adenocarcinoma
NCT03696030 -
Breast Cancer
NCT02547961 -
Breast Cancer
NCT04511871 -
Breast Cancer, Ovarian Cancer, Sarcoma
NCT02713984 -
Breast Cancer, Colorectal Cancer, Lung Cancer, Ovarian Cancer,
Pancreatic Adenocarcinoma
NCT01109095 -
Glioblastoma Multiforme
NCT03267173 -
Pancreatic Cancer
NCT00902044 -
Sarcoma
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present.